Et al. 2006; Pawlas and Malecki 2007; Cui et al. 2008; Selamoglu Talas et al. 2009) too as seleniumenriched natural merchandise e.g.: malt (Liu et al. 2006), yeast (Burk et al. 2006), broccoli (Rezanka and Sigler 2008), however the question on the very best type remains unsolved. The principle difficulties result from the narrow range amongst therapeutic and toxic dose of selenium (Hawkes et al. 2008) as well as in the dependence of its bioavailability around the type of supplementation (Burk et al. 2006). Considering that selenium is viewed as to become an antioxidant, as a constituent of one of the key antioxidative enzymesglutathione peroxidase (Ha and Smith 2009), several investigations have concerned relationships between selenium and oxidative balance in organisms (Ghodbane et al. 2011; Horky et al. 2012; Zhang et al. 2013). Ebselen, a ring selenoorganic compound of isoselenazole structure has been found to possess antioxidant properties though its negative effects have also been stated (Farina et al. 2004; Shi et al. 2006). An organoselenium compound has also been shown to exert protective effect against negative effects of cisplatin by the affecting of pro and antioxidative processes (Ghosh et al. 2013). Selenium is broadly distributed throughout the body, and its higher level occurs within the brain (van Eersel et al.2010). As an antioxidant or perhaps a principal constituent of brain selenoproteins, it seems to be an essential factor in sustaining of brain functions (Akbaraly et al. 2007). Associations in between low selenium levels and a drastically higher incidence of depression and also other damaging mood states such as anxiety, confusion, and hostility (Rayman 2000) also as cognitive impairment, Alzheimer’s disease (van Eersel et al.1471260-52-2 Data Sheet 2010) or brain tumors (Chen and Berry 2003) happen to be reported. Researchers have indicated that neurological disorders are usually linked with oxidative anxiety (Chauhan et al.56008-63-0 custom synthesis 2004; Mariani et al.PMID:24507727 2005) and selenium compounds may well display antioxidant and neuroprotective properties (Akbaraly et al. 2007). Having regarded these findings the aim of your present study was to evaluate the influence in the two newly synthesized organic selenocompounds with that exerted by acknowledged inorganic supplement sodium selenite, that is nonetheless utilized in clinical practice (Pagmantidis et al. 2008; Schnabel et al. 2008; Savory et al. 2012) and as a supplement of animal meals (Pavlovic et al. 2010), on oxidant processes in rat brain tissue.Materials and procedures Chemicals Two selenoorganic compounds have been synthesized in our chair: compound A (chain structure) four(otolyl)selenosemicarbazide of 2chlorobenzoic acid (Musik et al. 2002) and compound B (ring structure) three(2chlorobenzoylamino)2(otolylimino)4methyl4selenazoline (Musik et al. 2009).Cl O H CCH3 NH Cl Se C NH NH O CN N N Se CHH 3Ccompound Acompound BBiometals (2013) 26:763Animal experiment The experiment was carried out on adolescent male Wistar rats. Following three days of acclimatization the animals were randomly divided into 4 groups (ten animals every): group I (control with no selenium supplementation)treated with saline, group II treated with sodium selenite, group IIItreated with four(otolyl)selenosemicarbazide of 2chlorobenzoic acid, group IVtreated with three(2chlorobenzoylamino)2(otolylimino)4methyl4selenazoline. At the beginning with the experiment the weights of rats have been incorporated within a selection of 11050 g. Sodium selenite was given in form of water resolution. Organic compounds A and B provided to groups III and IV.