K, Dyck JR: Akt activity negatively regulates phosphorylation of AMP-activated protein kinase inside the heart. J Biol Chem 2003, 278(41):39422?9427. 59. Alvarez BV, Fujinaga J, Casey JR: Molecular Basis for angiotensin II-induced improve of chloride/bicarbonate exchange within the myocardium. Circ Res 2001, 89:1246?253. 60. Yannoukakos D, Stuart-Tilley A, Fernandez HA, Fey P, Duyk G, Alper SL: Molecular cloning, expression and chromosomal localization of two isoforms of AE3 anion exchanger from human heart. Circ Res 1994, 75:603?14. 61. de Cingolani GE C, Ennis IL, Morgan PE, Alvarez BV, Casey JR, de Hurtado MC C: Involvement of AE3 isoform of Na+-independent Cl-/HCO3- exchanger in myocardial pHi recovery from intracellular alkalization. Life Sci 2006, 78:3018?026. 62. Farias F, Morgan P, Chiappe de Cingolani G, Camilion de Hurtado MC: Involvement of your Na+-independent Cl-/HCO3- exchange (AE) isoform in the compensation of myocardial Na+/H+ isoform 1 hyperactivity in spontaneously hypertensive rats. Can J Physiol Pharmacol 2005, 83(five):397?04.Buy7-Amino-4-bromoisoindolin-1-one 63.Formula of 4-Bromoisoquinolin-5-ol Moor AN, Fliegel L: Protein kinase-mediated regulation from the Na+/H+ exchanger inside the rat myocardium by mitogen-activated protein kinase-dependent pathways. J Biol Chem 1999, 274(33):22985?2992. 64. Frey N, McKinsey TA, Olson EN: Decoding calcium signals involved in cardiac growth and function. Nat Med 2000, 6(11):1221?227. 65. Marks AR: Calcium as well as the heart: a question of life and death. J Clin Invest 2003, 111(5):597?00. 66. Villafuerte FC, Swietach P, Youm JB, Ford K, Cardenas R, Supuran CT, Cobden PM, Rohling M, Vaughan-Jones RD: Facilitation by intracellular carbonic anhydrase of Na+-HCO3- co-transport but not Na+/H+ exchange activity inside the mammalian ventricular myocyte. J Physiol 2013, 592:991?007. 67. Alvarez BV, Gilmour G, Mema SC, Shull GE, Casey JR, Sauv?Y: Blindness results from deficiency in AE3 chloride/bicarbonate exchanger. PLoS One 2007, 2:e839. 68. Kawasaki H, Otani H, Mishima K, Imamura H, Inagaki C: Involvement of anion exchange in the hypoxia/reoxygenation-induced changes in pHi and [Ca2+]i in cardiac myocyte. Eur J Pharmacol 2001, 411(1?):35?3. 69. Lai ZF, Nishi K: Intracellular chloride activity increases in guinea pig ventricular muscle through simulated ischemia. Am J Physiol 1998, 275(five Pt 2):H1613 1619. 70. Coats CJ, Elliott PM: Genetic biomarkers in hypertrophic cardiomyopathy. Biomark Med 2013, 7(4):505?16. 71. Xia Y, Karmazyn M: Obligatory function for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: proof for two distinct mechanisms for endothelin regulation.PMID:24605203 J Pharmacol Exp Ther 2004, 310(1):43?1. 72. Barry SP, Davidson SM, Townsend PA: Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol 2008, 40(10):2023?039. 73. Vargas LA, Alvarez BV: Carbonic anhydrase XIV inside the standard and hypertrophic myocardium. J Mol Cell Cardiol 2012, 52(three):741?52.74. Hentschke M, Wiemann M, Hentschke S, Kurth I, Hermans-Borgmeyer I, Seidenbecher T, Jentsch TJ, Gal A, Hubner CA: Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold. Mol Cell Biol 2006, 26(1):182?91. 75. Alvarez BV, Vilas GL, Casey JR: Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J 2005, 24:2499?511.doi:ten.1186/1471-2261-14-89 Cite this article as: Sowah et al.: Resistance to cardiomyocyte hypertrophy in ae3-/- mice, deficient within the AE3 Cl-/HCO3- exch.