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Development of new synthetic strategies for the preparation of phospholipids is amongst the important actions in advancing membrane chemistry and biochemistry now.1 The compounds are required for structural and dynamic studies of biomembranes and membrane-bound enzymes with particular emphasis on establishing structure-activity relationships with respect to phospholipid-phospholipid and phospholipid-protein interactions, too as for mechanistic elucidation of phospholipid metabolizing enzymes1?. Specifically, phospholipases A2 (PLA2s) comprise a big group of intracellular and secreted enzymes that catalyze the hydrolysis on the sn-2-ester bond of glycerophospholipids (Figure 1), yielding fatty acids for example arachidonic acid, and lysophospholipids.four The items.
